Metrology and Micro-Sensing for Biological Materials: From Cell Cultures to Complex Tissues

TECHNICAL OUTLINE

Non-destructive, label-free physical characterization of biological media is pivotal to advancing biomedical engineering, tissue diagnostics, and regenerative medicine. High-frequency electromagnetic and microwave sensing techniques provide unique, highly sensitive mechanisms to probe the complex dielectric signatures of biological systems across multiple structural levels—ranging from cellular suspensions and tissue scaffolds to intact organs and heterogeneous biological structures such as bone, muscle, and neural tissues.

However, achieving high measurement sensitivity, spatial resolution, and metrological repeatability across diverse biological matrices poses severe challenges. Key issues include sensor-sample coupling, environmental sensitivity, repositioning variability, and complex signal interpretation in lossy biological media.

This Special Session aims to convene researchers, metrologists, and engineers working at the intersection of sensor design, electromagnetic measurements, uncertainty assessment, and bio-data processing. The session will focus on state-of-the-art developments in physical sensor setups, high-precision measurement protocols, and advanced analytical pipelines designed to extract physiological insights without destructive sample preparation.

By addressing both hardware-level innovations and analytical/metrological methodologies, this session provides a comprehensive forum for discussing reliable, repeatable, and standardized high-frequency bio-sensing strategies.

ORGANIZED BY

Livio D’Alvia

Sapienza University of Rome, Italy

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Emanuele Rizzuto

Sapienza University of Rome, Italy

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Teemu Myllylä

University of Oulu, Finland

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KEYWORDS

Biological tissue characterization, Electromagnetic metrology, High-frequency biosensing, Non-destructive measurement, Dielectric spectroscopy, Multivariate analytics